Bristol Myers Squibb Research Scientist in Redwood City, California
The Research Scientist will join the Integrated Oncology Discovery Research team at Bristol-Myers Squibb in Redwood City, CA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immuno-biology.
The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in the oncology, immunology, immuno-oncology, protein engineering/antibody development and medicinal chemistry groups. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.
A B.S. with a minimum of 8 years, or an M.S. with a minimum of 6 years of industrial experience with strong scientific knowledge and research experience in cancer biology/cellular and molecular biology is required. Experience in immune-oncology research is a plus.
Demonstrated independence in experimental design, execution, data analysis and troubleshooting is required.
Knowledge of preclinical drug development including knowledge of designing assays and flowcharts to identify and optimize drug candidates is required.
Hands on experience with a wide range of in-vitro cellular and biochemical assays, including cell culture, western blotting, immunoprecipitation, ELISAs (MSD), reporter assays, siRNA/shRNA knockdown, CRISPR-mediated genome editing, qPCR, cloning, lentivirus generation and transduction is required.
Working knowledge of multi-color FACS including characterization of tumor infiltrating lymphocyte is highly desirable.
Experience with in vivo/ex vivo pharmacology, including rodent handling and common procedures including tissue processing is desired. Working knowledge of in-vivo PK, PD and efficacy studies is desirable.
Experience in data mining through use of desktop tools/interfaces and public databases (e.g., UCSC genome Browser, CBIO, GTex, Oncoland etc) is highly desirable.
Proficiency in utilizing software such as Graph Pad, Microsoft office etc. for data analysis and figure generation is required.
Ability to mentor more junior scientists and colleagues on best practices in the laboratory would be highly valued.
Attention to detail with excellent organizational and record keeping skills is a requirement.
Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.
This position is located in Redwood City, CA. There will be less than 10% travel.
Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled